博士生导师，免疫应答与免疫治疗全国重点实验室研究员，生医部青年杰出人才引进PI。博士毕业于香港大学医学院（联培于美国康奈尔大学HHMI实验室）。曾任香港大学研究助理教授，获香港特别行政区青年科学家奖、香港大学杰出研究奖等荣誉。2020年加入中科大生医部，主要从事NK细胞肿瘤免疫研究。研究成果以通讯/第一作者身份发表在Nature，Nature Immunology，Molecular Therapy，PNAS，JACS等国际高水平期刊，入选ESI高被引论文。获2项国家发明专利授权。承担国家自然科学基金-面上项目，中国科学院战略性先导科技专项B类，合肥综合性国家科学中心大健康研究院全球遴选项目-创新药物类等科研项目。现任中国老年医学学会委员，Advanced Science等期刊审稿人。
研究方向：
运用免疫学、化学生物学等多学科交叉技术，主要研究：
1、NK细胞肿瘤免疫：阐明肿瘤微环境抑制NK细胞功能的具体机制；鉴定新靶点，开发小分子药物干预策略以增强NK细胞的抗肿瘤功能。
2、NK细胞合成免疫学：合成具备精准靶向肿瘤能力的工程化NK细胞，用于NK细胞的临床免疫治疗。
代表性论文（*通讯作者；#第一作者）
1. Jing Jin#, Peidong Yan#, Dongyao Wang#*, Lin Bai#, Hao Liang, Xiaoyu Zhu, Huaiping Zhu, Chen Ding*, Haiming Wei*, Yi Wang*. Targeting lactylation reinforces NK cell cytotoxicity within the tumor microenvironment. Nature Immunology, June 10, 2025.
2. Yunjia Li#, Lin Bai#, Hao Liang#, Peidong Yan#, Hao Chen#, Zhuoxian Cao#, Yiqing Shen, Zhongyv Wang, Mei Huang, Bin He, Quan Hao, Yide Mei, Haiming Wei, Chen Ding*, Jing Jin*, Yi Wang*. A BPTF-specific PROTAC degrader enhances NK cell-based cancer immunotherapy. Molecular Therapy, 2025; 33(4):1566-1583.
3. Yunjia Li#, Yiqing Shen#, Hao Chen#, Lin Xue, Mei Huang, Haiming Wei, Jing Jin*, Yi Wang*. A heparanase-specific LYTAC degrader reinforces natural killer cell cytotoxicity within the tumor microenvironment. Cell Reports Physical Science, 2024, 5 (12).
4. Jing Jin#,* Lin Bai#, Dongyao Wang#, Wei Ding, Zhuoxian Cao, Peidong Yan, Yunjia Li, Lulu Xi, Yuxing Wang, Xiaohu Zheng, Haiming Wei, Chen Ding*, Yi Wang*. SIRT3-dependent delactylation of cyclin E2 prevents hepatocellular carcinoma growth. EMBO Reports, 2023, 24 (5), e56052.
5. Xinyuan Xu#, Qian Zhang#, Xufeng Wang#, Jing Jin#, Chengwei Wu#, Li Feng#, Xiuyan Yang, Mingzhu Zhao, Yingyi Chen, Shaoyong Lu, Zhen Zheng, Xiaobing Lan, Yi Wang*, Yan Zheng*, Xuefeng Lu*, Qiufen Zhang* Jian Zhang*. Discovery of a potent and highly selective inhibitor of SIRT6 against pancreatic cancer metastasis in vivo, Acta Pharmaceutica Sinica B, 2024; 14(3): 1302-1316.
6. Jing Jin#, Bin He#, Xiaoyu Zhang, Hening Lin*, Yi Wang*. SIRT2 reverses 4-oxononanoyl lysine modification on histones. J. Am. Chem. Soc., 2016, 138 (38), pp 12304–12307.
7. Hong Jiang#, Saba Khan#, Yi Wang#, Guillaume Charron, Bin He, Carlos Sebastian, Jin tang Du, Ray Kim, Eva Ge, Raul Mostoslavsky, Howard C. Hang, Quan Hao* & Hening Lin*. SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine. Nature. 2013, 496, (110–113).
8. Yi Wang#, Jing Jin#, Matthew Wai Heng Chung#, Ling Feng, Hongyan Sun, Quan Hao*. Identification of the YEATS domain of GAS41 as a pH-dependent reader of histone succinylation. Proc Natl Acad Sci U S A. 2018, Feb 20. pii: 201717664.
9. Yi Wang, Yi Man Eva Fung, Weizhe Zhang, Bin He, Matthew Wai Heng Chung, Jing Jin, Jing Hu, Hening Lin, Quan Hao*. De-acylation Mechanism by SIRT2 Revealed in the 1’-SH-2’-O-MyristoylIntermediate Structure. Cell Chemical Biology, 2017. 16; 24(3): 339-345.
10. Xiucong Bao#, Yi Wang#, Xin Li#, Xiao-Meng Li#, Zheng Liu, Tangpo Yang, Chi Fat Wong, Jiangwen Zhang, Quan Hao*, Xiang David Li*. Identification of ‘erasers, SIRT3’ for lysine crotonylated histone marks using a chemical proteomics approach. elife.2014; 3: e02999.
11. Yi Wang#, Sujit Dutta#, Helen Karlberg, Stéphanie Devignot, Friedemann Weber, Quan Hao, Yee Joo Tan, Ali Mirazimi, Masayo Kotaka.Structure of Crimean-Congo Hemorrhagic Fever Virus Nucleoprotein: Superhelical Homo-Oligomers and the Role of Caspase-3 Cleavage. J Virol. 2012 Nov; 86(22):12294–12303.
欢迎致力于免疫学/化学生物学交叉研究的本科生来本实验室攻读博士学位。实验室长期招聘博士后和科研助理，有意者请将个人简历（包括个人基本信息、教育和工作经历、论文发表及其他成果）发至邮箱：wy83@ustc.tsg211.com；联系电话：0551-63603117