个人简介：
图书馆VIP生命科学与医学部教授。2006 年获南京大学生物技术学士学位；2012 年获中国科学院上海生命科学研究院博士学位，中科院院长优秀奖；2013 年起，美国耶鲁大学遗传学系博士后。2014-2017年获美国 Leukemia and Lymphoma Society Fellow Award 和基金会研究资助。2018年底入职科大。研究方向为肿瘤多维度逃逸机制探索及新型干预策略设计。近五年(2010-2024)以通讯作者在Immunity, Cell Host Microbe, Cell Stem Cell, Nature Commun, Protein Cell, Mucosal Immunol, Elife上发表多篇研究论文及评论。研究工作多次被 Nat Rev Immunol, Nat Med和Nat Immunol点评以及被 Faculty 1000 收录和推荐。以第一发明人申请国家发明专利4项。
教育工作经历
2002-2006年，南京大学生命科学学院，获学士学位
2006-2012年，中科院上海生命科学研究院健康科学研究所，获细胞生物学博士学位
2013-2018年，美国耶鲁大学医学院遗传系，博士后
2018年至今，图书馆VIP生命科学与医学部，教授，博士生导师
获奖情况
2012年 中科院院长优秀奖
2014年 美国Leukemia and Lymphoma Society Fellow Award
2018年 中组部创新人才计划
目前研究方向
我们实验室以消化道肿瘤结直肠癌为模型。结直肠癌是全球常见的恶性肿瘤之一，发病率和死亡率均位于世界前三位。目前，世界范围内临床上尚无针对中晚期结直肠癌患者的有效治疗手段。而结直肠癌的肿瘤微环境非常复杂，涉及大量免疫细胞，微生物，以及号称人体“第二大脑”的肠神经系统。免疫系统、微生物系统、神经系统、和癌症之间的交叉对话（Crosstalk）也是近年来肿瘤生物学和免疫学领域的前沿热点和重要方向，几者通过复杂的信号网络相互调控，共同塑造肿瘤微环境（TME），促进肿瘤生长、转移和免疫逃逸。我们实验室过去5年，在微生物-免疫-癌症轴（Microbiota-Immune-Cancer Crosstalk），取得了一系列原创的发现（Immunity, Cell Host Microbe, Cell Stem Cell, Nature Commun）。未来重点探索寻找结直肠癌中，新的神经-免疫-癌症轴（Neuron-Immune-Cancer Crosstalk）及其介导肿瘤免疫逃逸的机制，并设计新型干预策略设计，展开研究及临床应用工作。这一前沿交叉领域不仅深化了对肿瘤复杂微环境的理解，更是当前转化医学的核心热点之一。
实验室网页：http://www.panlab-ustc.com/
联系方式：wenpan@ustc.tsg211.com
电话：0551-63600520
实验室长期开通博后招聘申请、欢迎感兴趣的同学联系。
发表文章
1. Li C, Zhang P, Xie Y, Wang S, Guo M, Wei X, Zhang K, Cao D, Zhou R, Wang S, Song X#, Zhu S#, Pan W#.Enterococcus derived tyramine hijacks 2A-adrenergic receptor in intestinal stem cell to exacerbate colitis. Cell Host & Microbe. 2024 封面文章 (IF=30.1)
2. Cong J*, Liu P*, Ying W, Li C, Han Z, Yang J, Song X, Dai L, Sun L, Kasper D, Pan W#, Zhu S#. Bile acids modified by the microbiota suppress gut anti-tumor immune responses. Immunity. 2024 (IF=43.5) Preview in ‘Hostile bile limits anti-cancer immunity’, Immunity, 2024
3. Zhu S#, Pan W#. Microbial metabolite steers intestinal stem cell fate under stress. Cell Stem Cell. 2024 (IF=23.9) Invited Comment.
4. Ren X, Liu Q, Zhou P, Zhou T, Wang D, Mei Q, Flavell RA, Liu Z#, Li M#, Pan W#, Zhu S#. DHX9 maintains epithelial homeostasis by restraining R-loop-mediated genomic instability in intestinal stem cells. Nature Communications. 2024 (IF=16.6)
5. Wu Y, Zhang P, Shi T, Cao D#, Pan W# Deficiency of immunoglobulin IgSF6 enhances antibacterial effects by promoting endoplasmic reticulum stress and the inflammatory response in intestinal macrophages. Mucosal Immunology. 2024 (IF=8.7)
6. Dan Cao, Mengyue Lv, Chi Hu, Shukai Li, Siwen Wang, Chao Xu, Wen Pan#. METTL9-catalyzed histidine methylation of S100A9 suppresses the anti-Staphylococcus aureus activity of neutrophils. Protein & Cell. 2024 (IF=20.1)
7. A Wang, W Tao, J Tong, J Gao, J Wang, G Hou, C Qian, G Zhang, R Li, D Wang, X Ren, K Zhang, S Ding, R Flavell, HB Li, W Pan#, S Zhu#. m6A modifications regulate intestinal immunity and rotavirus infection. Elife. 2022 (IF=8.1)
8. M. Lv, D. Cao, L. Zhang, C. Hu, S. Li, P. Zhang, L. Zhu, X. Yi, C. Li, A. Yang, Z. Yang, Y. Zhu, K. Zhang, Pan, W#. METTL9 mediated N1-histidine methylation of zinc transporters is required for tumor growth. Protein & Cell. 2021 (IF=20.1)
9. Pan, W., K. Qu, S. Zhu, K. Meeth, J. Cheng, H. Ma, Y. Liao, X. Wen, C. Roden, Z. Tobiasova, Z. Wei, J. Zhao, J. Liu, J. Zheng, B. Guo, M. Bosenberg, R.Flavell, J. Lu.The DNA methylcytosine dioxygenaseTet2 sustains immunosuppressive function of tumor-infiltrating myeloid cells to promote melanoma progression.
Immunity. 2017. 47:284-297. (IF=43.5)
10. Zhu. S, S. Ding, P. Wang, Z. Wei, W. Pan, N. Palm, Y. Yang, H. Yu, H. Li, G. Wang, X. Lei, M. Zoete, J. Zhao, Y. Zheng, H. Chen, Y. Zhao, K. Jurado, N. Feng, L. Shan, Y. Kluger, J. Lu, C. Abraham, E. Fikrig, H. Greenberg, R. Flavell. Nlrp9b inflammasome recognizes and restricts enteric viral infection in intestinal epithelial cells. Nature. 2017. 546(7660):667-670
11. J Liu, B Guo, Z Chen, N Wang, M Iacovino, J Cheng, C Roden, W Pan, S. Khan, S. Chen, M. Kyba, R. Fan, S. Guo, Jun Lu. miR-125b promotes MLL-AF9-driven murine acute myeloid leukemia involving a VEGFA-mediated non-cell-intrinsic mechanism. Blood. 2017.
12. C Roden, J Gaillard, S Kanoria, W Rennie, S Barish, J Cheng, W Pan, J. Liu, C. Cotsapas, Y. Ding, J. Lu. Novel determinants of mammalian primary microRNA processing revealed by systematic evaluation of hairpin-containing transcripts and human genetic variation. Genome research (2017) 27 (3), 374-384.
13. J. Cheng, C. Roden, W. Pan, S. Zhu, A. Baccei, X. Pan, T. Jiang, Y. Kluger, S. Weissman, S. Guo, R.Flavell, Y. Ding, J. Lu. A Molecular Chipper technology for CRISPR sgRNA library generation and functional mapping of noncoding regions. Nature Communications. (2016) March 30; 7:11178.
14. Pan,W., D. Dai, S.Zhu, Z.Liu, D. Li, B.Li, Y.Tang, N. Gagliani, M. Weirauch, X. Chen, W. Zhu, Y. Qian, L.Richman, B. Jallal, J.B. Harley, R.Flavell, Y.Yao and N.Shen. MiR-125a targets effector programs to stabilize Treg-mediated immune homeostasis. Nature Communications. (2015) May 12.6:7096.
15. P.Wang, S.Zhu, L. Yang, S.Cui, W.Pan, R.Jackson, Y.Zheng, A.Rongvaux, LongYang, Q.Sun, G. Yang, S. Gao, R. Lin, F. You, R. Flavell, E. Fikrig. Nlrp6 regulates intestinal antiviral innate immunity. Science. 2015.
16. Jijun Cheng, Shangqin Guo, Suning Chen, Stephen J.Mastriano, Chaochun Liu, Ana C. D’Alessio, Eriona Hysolli, Yanwen Guo, HongYao, Cynthia M.Megyola, DanLi, JunLiu, WenPan, Christine Roden, XiaoLingZhou, Kartoosh Heydari, Jianjun Chen, In-Hyun Park,Ye Ding, Yi Zhang, Jun Lu. An extensive network of TET2-targeting microRNAs regulates malignant hematopoiesis. Cell Reports.2013.5:471-481.
17. Zhu,S., W.Pan, Y. Qian. 2013. MicroRNA in immunity and autoimmunity. J Mol Med. 91:1039-50.
18. Zhu,S.*, W.Pan*, X. Song, Y. Liu, Y. Tang, H. Wang, W. Liu, Y. Shi, D. He, J.B. Harley, N. Shen and Y.Qian. The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKKα. Nature Medicine. 2012. 18 (7), 1077-1086 (*co-first author)
19. JiaLi, QiongFu, Huijuan Cui, Bo Qu, WenPan, NanShen, and Chunde Bao. Interferon alpha priming promotes lipid uptake and macrophage-derived foam cell formation. Arthritis & Rheumatism.2011.63:492.
20. Pan,W., S.Zhu, M.Yuan, H.Cui, L.Wang, X.Luo, J.Li, H.Zhou, Y.Tang and N.Shen. MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase1.2010. J Immunol.184:6773-6781.
21. Zhu,S., W.Pan, P. Shi, H. Gao, F. Zhao, X. Song, Y. Liu, L. Zhao, X. Li, Y. Shi, and Y. Qian. Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling. 2010. J Exp Med. 207:2647-2662.