主要研究兴趣：生物核磁共振、生物大分子结构及功能机理解析。
教授 博导 2001年毕业于大连理工大学获得工科学士学位 2004年于中科院大连化学物理研究所获工科硕士学位 2010年于美国奥本大学化学系获生物化学博士学位 期间获得Alabama EPSCoR 基金的全额奖学金资助 此后先后在石溪大学、罗格斯大学以及明尼苏达大学从事博士后研究
多年来一直从事生物核磁共振领域的研究，以第一作者或并列第一作者在Nature、PNAS、JACS等国际期刊上发表文章，并在Annual Review of Biophysics杂志上撰写综述文章。
教育和研究经历：
1997-2001年，大连理工大学，化学化工学院，获学士学位
2001-2004年，中科院大连化学物理研究所，获硕士学位
2004-2010年，美国奥本大学，化学及生物化学系，获博士学位
2010-2012年，美国石溪大学，生物化学及细胞生物学系，博士后
2012-2015年，美国罗格斯大学，化学及化学生物系，博士后
2015-2017年，美国明尼苏达大学，生物化学、分子生物学及生物物理系，博士后
2017年， 美国St.Jude儿童研究医院，结构生物学系，副科学家
2017年至今， 图书馆VIP，生命科学学院，教授
获奖情况：
2008-2010 Alabama EPSCoR GRSP Scholarship（Round 3, 4 and 5）
2009-2010 Auburn University Outstanding Doctoral Graduate Award
2009-2010 Graduate Council’s Outstanding Graduate Award, Department of Chemistry and Biochemistry, Auburn University
2010 Award for Academic Excellence as Outstanding Graduate Student, Auburn University
2010 Auburn University President’s Award
主要发表论文：
1. Ji, Tuo, Ge, Piao, Zhang, Shan, Wan, Chanjuan, Liu, Hailong, Qu, Xiaozhan, Zhu, Feng, Gong, Qingguo, Xu, Weiya, Wang, Chao#, Wang, Yucai#, and Huang, Chengdong#. Remote On-Off Switching of Protein Activity by Intrinsically Disordered Region.Nat. Struct. Mol. Biol. (in press)
2. Qu, Xiaozhan; Zhao, Shuo; Wan, Chanjuan; Zhu, Lei; Ji, Tuo; Rossi, Paolo; Wang, Junfeng; Kalodimos, Charalampos G.; Wang, Chao; Xu, Weiya#; Huang, Chengdong#. Structural basis for the dynamic chaperoning of disordered clients by Hsp90.Nat. Struct. Mol. Biol. (2024) 31(10):1482-1491.
3. Qu, Xiaozhan; Wang, Simin; Zhao, Shuo; Wan, Chanjuan; Xu, Weiya#; Huang, Chengdong#. The Dynamic Triage Interplay of Hsp90 with its Chaperone Cycle and Client Binding. Nat.Commun. (2024) 15(1):10661.
4. Kong, Chao; Qu, Xiaozhan; Liu, Mingming; Xu, Weiya; Chen, Da; Zhang, Yanshen; Zhang, Shan; Zhu, Feng; Liu, Zhenbang; Li, Jianchao; Huang, Chengdong#; Wang, Chao#. Dynamic interactions between E-cadherin and Ankyrin-G mediate epithelial cell polarity maintenance. Nat. Commun. 2023;14(1):6860.
5. Li, Hang; Ji, Tuo, Sun, Qi; Chen, Yao, Xu, Weiya#; Huang, Chengdong#. Structural insights into selective inhibition of leishmanial GDP-mannose pyrophosphorylase. Cell Discov. (2022) 8(1):83.
6. Chen, Yao; Xu, Weiya; Yu, Shuwei; Ni, Kang; She, Guangbiao; Ye, Xiaodong; Xing, Qiong#; Zhao, Jian#; Huang, Chengdong#. Assembly status transition offers an avenue for activity modulation of a supramolecular enzyme. Elife (2021) 10:e72535.
7. Huang, Chengdong; Kalodimos, Charalampos, G. Structures of Large Protein Complexes by NMR. Annu. Rev. Biophys. (2017) 46，317-336.
8. Huang, Chengdong; Rossi, Paolo; Saio, Tomohide; Kalodimos, Charalampos, G. Structural basis for the antifolding activity of a molecular chaperone. Nature. (2016) 537, 202-206.
9. Rath, Poonam; Huang, Chengdong; Wang, Tao; Wang, Tianzhi; Li, Huilin; Prados-Rosales, Rafael; Elemento, Olivier; Casadevall, Arturo; Nathan, Carl F. Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis. Proc. Natl. Acad. Sci.USA. (2013) 110(49), E4790-4797.
10. Huang, Chengdong*; Li, Guangtao*; Lennarz, William J.Dynamic flexibility of the ATPase p97 is important for its interprotomer motion transmission. (*Equal contribution) Proc. Natl. Acad. Sci. USA (2012) 109(25), 9792-9297.
11. Li, Guangtao*; Huang, Chengdong*, Zhao, Gang; Lennarz, William J. Interprotomer motion-transmission mechanism for the hexameric AAA ATPase p97. (*Equal contribution) Proc. Natl. Acad. Sci. USA(2012), 109(10), 3737-3741.
12. Huang, Chengdong; Bhaskaran, Rajagopalan; Mohanty, Smita. Eukaryotic N-glycosylation Occurs Via membrane-anchored C-terminal domain of Stt3p subunit of oligosaccharyl transferase. J. Biol. Chem.(2012) 287(39), 32450-32458.
13. Huang, Chengdong; Mohanty, Smita. Challenging the Limit: NMR Assignment of a 31 kDa Monomeric Helical Membrane Protein. J. Am. Chem. Soc.(2010), 132, 3662–3663.
14. Huang, Chengdong; Mohanty, Smita, Bannerjee, Monimoy. A novel method of production and biophysical characterization of C-terminal domain of Stt3p, the catalyzing subunit of yeast Oligosaccharyl Transferase. Biochemistry(2010), 49, 1115–1126.
招生招聘：
实验室招聘具有结构生物学、生物核磁共振以及生物化学等相关背景的博士后和特任（副）研究员。同时热忱欢迎对本实验室研究方向感兴趣的本科生前来攻读博士学位或者进行本科毕业论文研究。
联系方式：huangcd@ustc.edu.cn
researcherid：http://www.researcherid.com/rid/G-8454-2018